Plasma Concentration Studies
Epithalon
Epitalon
Epithalone
AEDG Peptide
Ala-Glu-Asp-Gly
CAS: 307297-39-8
A 4-amino acid synthetic tetrapeptide modeled on pineal gland epithalamin that activates telomerase and modulates circadian gene expression in preclinical and early human studies. Premium Research Peptide.
99%+ Purity
Purity Tested
Research Use Only
Laboratory Use
Peptide Profile
Peptide Type
Certificate of Analysis
Third Party Tested by Freedom Diagnostics
Compound Information
Technical specifications
What Is Epithalon?
Stability Information
Protect from light
Avoid repeated freeze-thaw
Store in original sealed vial
Lyophilized (powder)
-20°C • up to 2 years
Reconstituted
2-8°C • up to 30 days
Sources & References
Peer-reviewed research
International Journal of Molecular Sciences
Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties
2025 • DOI: 10.3390/ijms26062691 ... PMID: 40141333
Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł
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Bulletin of Experimental Biology and Medicine
Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
2003 • DOI: 10.1023/a:1025493705728 ... PMID: 12937682
Brines M, Patel NSA, Villa P, et al.
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Bulletin of Experimental Biology and Medicine
Peptide Promotes Overcoming of the Division Limit in Human Somatic Cells
2004 • DOI: 10.1023/b:bebm.0000038164.49947.8c ... PMID: 15455129
Khavinson VKh, Bondarev IE, Butyugov AA
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Bulletin of Experimental Biology and Medicine
Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes
2019 • DOI: 10.1007/s10517-019-04664-0
Khavinson VKh, Pendina AA, Efimova OA, et al.
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Molecules
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
2020 • DOI: 10.3390/molecules25030609... PMID: 32019204
Khavinson V, Diomede F, Mironova E, et al.
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Mechanisms of Ageing and Development
Effect of Epitalon on the Lifespan Increase in Drosophila melanogaster
2000...
Khavinson VKh, Izmaylov DM, Obukhova LK, Malinin VV
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Mechanisms of Ageing and Development
Effect of Synthetic Thymic and Pineal Peptides on Biomarkers of Ageing, Survival and Spontaneous Tumour Incidence in Female CBA Mice
2001...
Anisimov VN, Khavinson VKh, Mikhalski AI, Yashin AI
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Bulletin of Experimental Biology and Medicine
Regulatory Effect of Epithalon on Production of Melatonin and Cortisol in Old Monkeys
2001...
Goncharova ND, Khavinson BK, Lapin BA
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International Journal of Cancer
Inhibitory Effect of the Peptide Epitalon on the Development of Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice
2002... PMID: 12209581
Anisimov VN, Khavinson VKH, Provinciali M, et al.
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Journal of Restorative Medicine
Improving Biological Age, Telomere Length, and Cognition: A Case Study
2024...
Published case report
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Bulletin of Experimental Biology and Medicine
Molecular Cellular Mechanisms of Peptide Regulation of Melatonin Synthesis in Pinealocyte Culture
2012...
Khavinson VK, Linkova NS, Kvetnoy IM, et al.
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Advances in Gerontology
AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts
2022...
Gutop EO, Linkova NS, Kozhevnikova EO, et al.
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