Plasma Concentration Studies

SEMAX / SELANK

ACTH (4-10)

ACTH (4-7)-Pro-Gly-Pro

Met-Glu-His-Phe-Pro-Gly-Pro

MEHFPGP

CAS: 80714-61-0

A 7-amino acid synthetic heptapeptide analog of ACTH (4-10) that upregulates BDNF expression and modulates the TrkB signaling pathway, studied for cognitive enhancement and neuroprotection in clinical research. Premium Research Peptide.

Dosage

20 MG

Clear

99%+ Purity

Purity Tested

Research Use Only

Laboratory Use

Peptide Profile

Peptide Type

Certificate of Analysis

Third Party Tested by Freedom Diagnostics

99.11%

Purity

Variant

Semax 10mg

Lot #

Blue Cap

Labeled

10mg

Actual

12.23mg

Tested

Apr 14, 2026

Compound Information

Technical specifications

Molecular Profile

What Is Semax?

Synthetic heptapeptide analog of ACTH (4-10) with C-terminal Pro-Gly-Pro extension for enhanced stability

Type

Synthetic heptapeptide

CAS Number

80714-61-0

Molecular Formula

C37H51N9O10S

Molecular Weight

813.9 g/mol

Amino Acids

7 residues

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro

Storage Requirements

Stability Information

Handle with care to maintain potency

Lyophilized (powder)

-20°C • up to 2 years

Reconstituted

2-8°C • use within 4 weeks

Nasal spray (0.15%)

2-8°C • 30 days after opening

Sources & References

Peer-reviewed research

Brain Research

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat...

2006 • DOI: 10.1016/j.bra...

PMID: 16996037

Dolotov OV, Karpenko EA, Inozemtseva

BMC Genomics

The peptide semax affects the expression of genes related to the immune and vascular systems in rat...

2014 • DOI: 10.1186/1471-...

PMID: 24661656

Medvedeva EV, Dmitrieva VG,

Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

The efficacy of semax in the treatment of patients at different stages of ischemic stroke

2018

PMID: 29798983

Journal of Molecular Neuroscience

Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus,...

2010 • DOI: 10.1007/s120...

PMID: 19662538

Shadrina M, Kolomin T, Agapova T, et...

International Journal of Molecular Sciences

Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Molecular Level

2020

PMID: 32575851

Alzheimer's Drug Discovery Foundation

Semax - Cognitive Vitality For Researchers

PubChem Database

Semax - Compound Summary (CID 9811102)

All the research peptides you need, with the peace of mind and research community at your fingertips.